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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

FORMULATION AND STUDY OF ELEMENTARY OSMOTIC TABLET OF ACARBOSE

Dr. Ganesh Sanker S.* and Dr. (Sr.) Molly Mathew

ABSTRACT

In this study a controlled Elementary osmotic pump for controlled release of Acarbose was developed based on the osmotic technology using an osmogen and evaluated the various parameters. Acarbose is very high soluble anti-hypoglycemic drug which is an ideal candidate for zero order drug delivery release. The formulation comprise of a core component with a semi-permeable coating polymer and cellulose acetate.The effect of osmogen, change in composition of coating solution, and various physiochemical studies were conducted. The FT-IR studies revealed that no physiochemical interaction between excipients and drug. The in vitro study of Acarbose osmotic tablet shows a significant effect on drug release up to 12h. The drug release kinetic of optimized formulation follows zero order non fickian release mechanism. The observed data’s were found to be very close to predicted values of most satisfactory formulation which demonstrates the feasibility of the optimization procedure in successful development of elementary osmotic tablet of Acarbose.

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