World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , 

World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

INFLAMMATION, HORMONE IMBALANCE: A PREDISPOSING FACTORS OF BENIGN PROSTATIC HYPERPLASIA: GENERAL REVIEW

Ibtisam Jasim Sodani*

ABSTRACT

Benign prostatic hyperplasia (BPH) continues to be a significant healthcare problem world-wide. Recently published data suggest that clinical BPH, which is hallmarked by the occurrence of moderate-to-severe lower urinary tract symptoms (LUTS), occurs in about one quarter of men in their 50s, one third of men in their 60s, and about half of all men 80 years or older. Inflammation of the prostate may represent a mechanism for hyperplastic changes to occur in the prostate. There are a variety of growth factors and cytokines that may lead to a proinflammatory process within the prostate. In fact prostatic inflammation may represent an important factor in influencing prostatic growth and progression of symptoms. Prostatitis, a histological diagnosis, has evolved over the years to describe a clinical syndrome that was believed to be associated with prostatic inflammation. In addition, the altered endocrine status of aging men is likely to be of importance for development of the disease since testosterone and growth hormone (GH) levels decrease with age, whereas estrogen levels increase. Conflicting data exist on changes in prolactin hormone (PRL) levels with increasing age. As the number of men afflicted by these diseases will only continue to grow with the aging population, further understanding of the role of inflammation in BPH and hormone imbalance will expand our understanding of BPH pathogenesis, its histological and clinical progression.

[Full Text Article]

Powered By WJPMR | All Right Reserved

WJPMR