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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

ADVERSE DRUG REACTIONS CAUSED DUE TO ANTITUBERCULAR DRUG THERAPY IN PATIENTS RECEIVING FIRST LINE TREATMENT - A RETROSPECTIVE OBSERVATIONAL STUDY

Rajesh Bhaskar Nawale*, P. S. Jirvankar, Nikita Anil Kantak, Aishwarya Atul Badhe, Ankita Ashok Kirdak, Tanvi Sharad Mathurvaishya

ABSTRACT

Tuberculosis (TB) is a communicable infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis). India accounts for 1/4th of global TB burden. Primary infection of TB is initiated by the alveolar implantation of organisms in droplet nuclei. General signs and symptoms include fever, chills, night sweats, loss of appetite, weight loss, and fatigue. Significant finger clubbing may also occur. Treatment with anti Tb agent induces significant adverse drug effects which might remain unreported. The retrospective observational study was carried out in 65 patients; suffering from tuberculosis receiving first line treatment from In-patient department (IPD) in Tertiary Care Hospital at Aurangabad The primary objective of study includes monitoring patients for ADRs. The secondary objective of study is to counsel patient about means to decrease effects to improve adherence. Detailed history was taken regarding the demographic profile, present complaints, past history of TB, history of any addiction, family history of TB. Detailed general and systemic examination was done to find out any abnormalities. Form the study it was concluded that the majority of adverse drug reactions observed were mild and includes gastro-intestinal upset (nausea, vomiting and abdominal pain). There was no marked sign of hepatotoxicity. Special intervention and knowledge to cure these mild adverse effects can lead to increased patient compliance.

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