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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

ANTIFUNGAL EFFICACY OF WATER SOLUBLE CHITOSAN BASED DENTURE CLEANSER – AN INVITRO STUDY

Dr. V. Harshitha M.*, Dr. Shruthi Eshwar, Dr. Supriya Manvi, Dr. B. K. Srivastava and Dr. Vipin Jain

ABSTRACT

Introduction: Chitosan (CHS) is a very versatile natural biomaterial that has been explored for a range of bio-dental applications. Many studies have revealed the antimicrobial and anti-fungal property of chitosan but the role of anti-fungal activity of water soluble chitosan was not established. So, the present study aimed at evaluating the antifungal activity of carboxy methyl chitosan and synergistic effect of chitosan and sodium perborate against candida species. Materials and methods: An Invitro study was carried out to evaluate the antifungal activity of carboxy methyl chitosan and its synergistic effect with sodium perborate by agar diffusion method. Stock solutions of chitosan and perborate solutions were prepared and different dilutions were loaded into the wells prepared in the Muller Hinton Agar media. The agar plats were then incubated at 37°c for 24 hrs and then examined for zone of inhibition around the wells. Results: The agar plates with different dilutions of chitosan, sodium perborate and plain water did not show any zones of inhibition whereas the agar plate with mixture of chitosan and perborate solution showed equal zones of inhibition around the wells irrespective of different dilutions. Conclusion: Anti-fungal activity of carboxy methyl chitosan and sodium perborate solution were not found individually whereas the synergistic effect of these two solutions was established.

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