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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVOLUTION OF 4,6-DIPHENYL-1,6-DIHYDROPYRIMIDIN-2-OL DERIVATIVES

T. Kala Praveen*, Mounika Perli, Flourence Thangirala, Raja Kumari Nomburi, Uma Devi Muvva and K. M. Anitha

ABSTRACT

The pyrimidine derivatives were synthesized from chalcone as intermediate compound .the chalcones were reacted with urea in presence of glacilal cetic acid and sodim acetate to form cyclic compound pyrimidine-2-ol derivatives and the structures were confirmed by spectral evidence. The compounds were tested for anti microbial activity and antioxidant activity using diffusion method by measuring the Zone of the inhibition in mm and DPPH measuring by measuring the percentage of inhibition. In these test compounds, PR-06 shows maximum anti bacterial activity than compare with other compounds, with Bacillus substilis zone of inhibition 24,26,30 mm at 50 ?g/ml,100 ?g/ml, 150 ?g/ml, Staphylococcus aureus zone of inhibition 25,28,30 mm at 50 ?g/ml,100 ?g/ml, 150 ?g/ml, with Pseudomonas vulgaris zone of inhibition 26,27,34 mm at 50 ?g/ml,100 ?g/ml, 150 ?g/ml, with Escherichia coli the zone of inhibition 24,26,34 mm at 50 ?g/ml,100 ?g/ml, 150 ?g/ml compare with the standard streptomycin. In case of anti oxidant activity the compound PR-02 shows inhibition at 54.63 ± 0.18, 101.31±0.33, 145.25±0.32, 260.41±0.54, 380.24±0.45 at concentration of 100, 200, 300,400, 500 ?g/ml respectively compare with the standard ascorbic acid.

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