Abstract

B. Venkatesh, Yamparala Krishnakumari, Kelavathu Anjaiahnaik, Muravani Satyaraj and V. Jhansi Priya Marabathuni*

ABSTRACT

In the present research work gastro retentive floating matrix formulation of Lafutidine by using various polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers Xanthan gum, guar gum and Sodium Alginate as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations Only Xanthan gum, Sodium Alginate highest concentrations (60 mg) retards the drug release upto 12 hours and the drug release 96. 25%, 95. 81% respectively. In this Xanthan gum releases the more drug release when compared to Sodium alginate. So F3 Formulation considered as optimized formulation. Optimised formulation F3 was kept for release kinetic studies. From the above graphs, it was evident that the formulation F3 was followed the Peppas release mechanism.