World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

Abstract

IN VITRO ANTHELMINTIC ACTIVITY OF NOVEL BENZIMIDAZOLE DERIVATIVES FROM O-PHENYLENE DIAMINE

Ch. M. M. Prasada Rao*, A. Jala Lakshmi, Y. Grace Mani, B. Santhi Sudha, P. Bhanu Rekha, Satyaprakash Kumar, D. Dhachinamoorthi

ABSTRACT

The present study is an attempt to explore the anthelmintic activity of Benzimidazole by molecular docking with tubulin and in vitro activity against adult Indian earthworms, Pheretima posthuma. The time taken for each worm for paralysis and death were determined. A benzimidazole derivative binds very efficiently within the active pocket of tubulin which is better when compared to orientation of standard drug, Piperazine citrate. In vitro results correlated with the in silico studies. The time taken for paralysis and death with benzimidazole 2 at 80 mg/ml was comparable to standard Piperazine citrate.

[Full Text Article]    [Download Certificate]

Powered By WJPMR | All Right Reserved

WJPMR