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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

IN VITRO ANTHELMINTIC ACTIVITY OF NOVEL BENZIMIDAZOLE DERIVATIVES FROM O-PHENYLENE DIAMINE

Ch. M. M. Prasada Rao*, A. Jala Lakshmi, Y. Grace Mani, B. Santhi Sudha, P. Bhanu Rekha, Satyaprakash Kumar, D. Dhachinamoorthi

ABSTRACT

The present study is an attempt to explore the anthelmintic activity of Benzimidazole by molecular docking with tubulin and in vitro activity against adult Indian earthworms, Pheretima posthuma. The time taken for each worm for paralysis and death were determined. A benzimidazole derivative binds very efficiently within the active pocket of tubulin which is better when compared to orientation of standard drug, Piperazine citrate. In vitro results correlated with the in silico studies. The time taken for paralysis and death with benzimidazole 2 at 80 mg/ml was comparable to standard Piperazine citrate.

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