FORMULATION, CHARACTERIZATION & EVALUATION OF SOLID LIPID NANOPARTICLES OF CARVEDILOL
Neeraj*, Nidhi Saini, Babita, Rakesh Kumar, Neelam Kumari, Rakesh Kumar and Mehar Priya Sharma
ABSTRACT
Aims: The objective of the present research study was to formulate and characterize a lipid based delivery system for Carvedilol, to develop a controlled release formulation, to increase the bioavailability of Carvedilol by avoiding its first-pass metabolism, to increase the biological half-life of Carvedilol achieved successfully. Study Design: Design and development of formulation includes short listing of ingredients for the formulation, effect of various processes as well as formulation parameters of hot homogenization followed by ultrasonication method, and effect of drug concentration. Characterization of SLNs, which includes, entrapment efficiency (%), Drug loading (%), In-vitro drug release using dialysis bag diffusion technique, Particle size analysis, transmission electron microscopy, and charge determination.
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