COULD THE RELATIONSHIP BETWEEN CRP AND ALBUMIN / GLOBULIN RATIO BE A CLINICAL ACTIVATION INDICATOR IN BEHÇET'S DISEASE?
Dr. Ramazan Ilyas Oner* and Hakan Sezgin Sayiner
Aim: The aim of the study was to analyse the relationship between the sedimentation rate and Albumin/Globulin (A/G) ratio along with the CRP level which is considered as an indicator of Behçet’s disease (BD) activation. Method: Fifty patients who were diagnosed with BD were included in this study. CRP levels, sedimentation rate, total protein and albumin levels of patients were retrospectively checked. The patients were classified into two groups: group 1 (0 – 0.8 mg/dl) consisting of those with CRP levels within the normal range and group 2 consisting of those with CRP levels higher than the normal range (CRP> 0.8 mg/dl). Results: There was a statistically significant difference between patients in group 2 and those in group 1 with respect to the sedimentation rate (p = 0.001) and A/G ratio (p = 0.002). Additionally, there was a statistically significant negative correlation between A/G ratio and both CRP levels (r = ? 0.405, p = 0.004) and sedimentation rates (r = ? 0.592, p = 0.000). Conclusion: We believe that in addition to CRP levels, the sedimentation rate and A/G ratio, which are frequently used in clinical evaluation and are easily accessible, may be utilised as indicators of BD disease activity. Therefore, further investigations are needed to clarify the role of these mediators in the BD.[Full Text Article]