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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

STUDY ON ANTIMALARIAL ACTIVITY OF CYPERUSROTUNDUS LINN (MYET-MOUN-NYIN) BY PLASMODIUM BERGHEI MOUSE MODEL

Myint Myint Win*, Zaw Lin and Mar Too Nyi Bu

ABSTRACT

Malaria is a common, most lethal parasitic and life-threatening disease in many tropical and subtropical areas. Attack of the disease can be very severe and can even lead to death if they remain untreated. The commonly used standard antimalarial drugs were becoming increasingly resistant by Plasmodium falciparum (P. faliparioum), the aetiologic agent of severe type of clinical malaria. This study as attempted as part of the search for new antimalarial drugs from herbal plant resources. In this study, crude extract from Cyperusrotundus Linn (Myet-Moun-Nyin) was investigated for antimalarial activity by in vivo Plasmodium berghei mouse model system and found to have supperessive action on malarial parasite. A compound, ?-Cyperone, extracted from Cyperusrotundus Linn (Myet-Moun-Nyin) was investigated for antimalarial activity by the same method. The data indicated that this compound has potential to be used as antimalarial drug. ED50 was studied on ?-Cyperone and was observed to be 13.11mg per kg per day.

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