REVERSAL OF CHRONIC ANTHRACYCLINE-INDUCED HEART FAILURE: A CASE REPORT
T. Raja and Satya Srinivas Appala*
ABSTRACT
Anthracycline chemotherapy is a major cause of medication-induced cardiomyopathy. The cumulative dose typically determines the likelihood of toxicity, 1 which is attributed to the production of toxic oxygen free radicals. Vacuolation, irreversible ultrastructural damage, and the replacement of myocytes with fibrous tissue eventually result, wahich cause late-onset dilated cardiomyopathy and chronic heart failure which is usually considered to be irreversible. We report the case of a woman whose chronic anthracycline-induced cardiomyopathy was treated with appropriate heart failure medication. The patient’s clinical status improved thereafter. with normal LV systolic function( EF-65.%).
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