HEPATOPROTECTIVE AND ANTITUMOR ACTIVITY OF PHENOLIC CONTENT OF TRICHODESMA EHRENBERGII SCHEWIENF. EX BOISS. AERIAL PARTS
Fatma A. Ahmed, Amani M. D. El-Mesallamy and Taha A. I. El-Bassossy*
ABSTRACT
Eleven phenolic compounds [(1) ferulic acid, (2) Quercitrin, (3) Astralgalin, (4) Cynaroside, (5) Epicatechin, (6) Gallic acid, (7) Ellgaic acid, (8) Quercetin, (9) Kaempferol, (10) Luteolin and (11) 6-Hydroxy-4'methoxy aurone] were isolated and identified from the 70% methanolic extract of T.ehrenbergii Schewienf .ex Boiss. aerial parts by using different chromatographic methods. The acute toxicity examination for aqueous methanolic extract of T.ehrenbergii aerial parts clearly indicated that, the extract is non-toxic and safe in rats up to 4500 mg/kg b.wt. So, two specific doses (450 and 225 mg/kg) were used for hepatoprotective activity of T.ehrenbergii aerial parts extract. Results show a potent hepatoprotective activity. It alleviated significantly the toxic effect of carbon tetrachloride in rats by improvement of different biochemical parameters compared with carbon tetrachloride treated group. The methanolic extract showed a potent cytotoxicity against liver carcinoma cell line (HEPG-2) at concentration 38.4 ?g/ml and lung carcinoma cell (A-549) at concentration 55.6 ?g/ml.
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