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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

FABRICATION AND CHARACTERIZATION OF ANTITUSSIVE DISPERSIBLE TABLETS

Lakshmi Prasanna J.*, Supriya J., Sudhakar Babu AMS

ABSTRACT

The aim of the study was to fabricate and characterize antitussive disperisbe tablets using super disintegrants. Dispersible tablets of Guaiphenesin were prepared by direct compression method using Sodium starch glycollate(SSG), Croscarmellose sodium(CCS) and Crospovidone(CP). Different concentrations of super disintegrants SSG (5%, 10% and 15%), CCS (5%, 10% and15%) and CP (5%, 10% and15%) were examined to know their effect on in vitro drug release. Tablets were characterized for their pre compression and post compression parameters. The in vitro drug release studies were carried out in pH 6.8 phosphate buffer. Of all the formulations, tablets containing 15% of SSG, CCS and CP showed good drug release.

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