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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

CORRELATION OF CHROMOSOMAL ABERRATIONS WITH MULTIORGAN DYSFUNCTION IN PERINATAL ASPHYXIA

A. Manoj*, B. Vishnu Bhat, C. Venkatesh, Z. Bobby

ABSTRACT

The current study evaluated oxidative stress induced DNA damage and chromosomal aberrations on multiorgan dysfunction in perinatal asphyxia. Eighty term asphyxiated babies were recruited in this study and all of them had organ dysfunction. Conventional Cytogenetic screening test was used for identification of chromosomal aberrations. Oxidative stress was assessed by estimation of serum MDA level. Chromatid breakage, dicentric chromosomes, inter chromatid connections, ring chromosomes and acentric chromoses were recorded.. The chromosomal aberrations in two, three, four and five systems were 2.75± 0.942072, 3.052632±0.998614, 3.25±1.409787 and 4.85±0.726292 respectively. Chromosomal aberrations increased with severity of asphyxia and it was well associated with oxidative stress (p <0.05). Involvement of Organ systems in perinatal asphyxia positively correlated with Chromosomal damage (p <0.05).

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