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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

CORRELATION OF MICRONUCLEUS SCORE WITH ORGAN DYSFUNCTION IN PERINATAL ASPHYXIA

A. Manoj*, B. Vishnu Bhat, C. Venkatesh, Z. Bobby

ABSTRACT

The present study was conducted to correlate the micronucleus score with organ dysfunction and severity of perinatal asphyxia. Severity of asphyxia and organ system involvement of babies with perinatal asphyxia was assessed. Blood samples were collected from babies for estimation of MDA (Malondialdehyde), micronucleus score and other investigations. Clinical and biochemical findings were correlated with organ system involvement. Among eighty term asphyxiated babies 25% had five and four system involvement whereas 35% had three systems and 23.8% had two system involvement. Micronucleus score was significantly increased with number of systems affected (P<0.001). There was significant Positive correlation between micronucleus score and oxidative stress (P <0.001). Micronucleus score also had significant correlation with Apgar score, Sarnat and Sarnat score and Seizure (P <0.001).

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