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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

STUDY OF SERUM CREATINE PHOSPHOKINASE LEVELS AS A PROGNOSTIC BIOMARKER AMONG CASES OF ORGANOPHOSPHATE POISONING IN A TERTIARY HEALTH CARE CENTER

Rode Vikram and Jadhav Nitin*

ABSTRACT

Background: OPCs constitute a heterogeneous category of chemicals specifically designed for the control of pests, weeds or crop diseases. The clinical features of organophosphate poisoning are a combination of effect of acetylcholine stimulation on various kinds of acetylcholine receptors such as muscarinic and nicotinic receptors. Estimation of serum or RBC cholinesterase level and electrodiagnostic tests is helpful in confirming the diagnosis. The purpose of present study was to study epidemiology, clinical features of OPP cases; various clinical grades were evaluated and compared with outcomes of OPP. Hence an attempt was made to study clinical significance of various laboratory parameters in prediction of prognosis in OPP such as serum ChE and Serum CPK, which might help in early recognition, prognostication and optimal utilisation of resources. Materials and methods: The present Prospective, Observational, Cross Sectional Study was conducted among 130 cases of Organophosphate poisoning admitted to department of General Medicine within 12 hours of consumption of poison and of age >18 years, at a tertiary care centre. Results: In this study 83.07 % cases consumed OPPs with suicidal intention whereas 22 cases (16.92 %) of poisoning were accidental in nature. Chlorpyrifos (62 cases) and Dichlorvos (54 cases) were the most commonly consumed organophosphate poisoning compounds. The mean Cholinesterase level was found to be 2969.26 IU/L with standard deviation of 1521.51 IU/L, whereas mean Creatine Phosphokinase level was 359.33 IU/L with standard deviation of 169.4 IU/L. Conclusions: The crux of the present study is that prognostic marker in cases of OP poisoning should be sensitive, reliable, accessible at peripheral healthcare facilities and affordable to general population at cheaper expenses. Instead of using serum Cholinesterase as a prognostic marker in OPP cases.

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