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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

A STUDY ON EVALUATION OF THE ROLE OF PRE-EXISTING ANTIPLATELET THERAPY IN INTRACRANIAL HEMORRHAGE BY USING STANDARDIZED SCORES: PILOT STUDY

Dr. Malini Gopinath*, Krishnaja R.J., Lekshmi Johnson Maithyli, Babitha M.

ABSTRACT

Background: Intra-cerebral haemorrhage (ICH) is defined as bleeding into the parenchyma of the brain. Aim & Objective: The purpose of the study was to evaluate the role of pre-existing anti-platelet therapy in causing and worsening of intracranial haemorrhage. Materials and Methods: Consecutive thirty patients of either sex more than 18 years of age with intracranial haemorrhage were taken and divided equally on the basis of their pre-existing anti-platelet therapy. In order to analyse the relationship between pre-existing anti-platelet use and occurrence as well as worsening of intracranial haemorrhage, a number of parameters including history of anti-platelet use*, GCS*, MRS*, ICH risk score*, S2TOP BLEED SCORE*, GOS*, etc., were collected and analysed properly. All statistical analysis was performed with SPSS and Minitab software. Result: The observed difference in risk of major bleeding defined by S2TOP BLEED score was 33.3% higher (95% confidence interval -1.6090 to 59.2923) in patients on pre-existing anti-platelet therapy. By statistical comparison of proportions, after analysing the severity at the admission time, ICH risk score, unfavourable functional outcome and mortality rate were found to be higher in patients on pre-treatment with anti-platelets. Conclusions: Based on the study, pre-treatment with anti-platelet agents is found to play a role in worsening or unfavourable outcome in patients with Intra-cranial haemorrhage.

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