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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL FILMS OF LISINOPRIL

Priyanka Dova*, Sundaraseelan J. and Kusuma K.

ABSTRACT

The aim of the present study was to formulate the mucoadhesive buccal films and selection of most satisfactory formulation by in-vitro evaluation. Buccal delivery is considered to be an important alternative to the per-oral route for the systemic administration of drugs. The mucosa is relatively permeable, well supplied with both vascular and lymphatic drainage. Lisinopril is an anti-hypertensive drug with an oral bioavailability of 25% due to extensive first pass metabolism. Hence, this research work was designed to enhance the biovailability of Lisinopril. Buccal films are prepared by using solvent casting method. In the present study Lisinopril buccal films were prepared by solvent casting method using different film forming polymers like HPMC, PVP K30 and PG as plasticizer. Buccal films of Lisinopril formulated from F1 to F10 are smooth, transculent with good flexibility were evaluated and characterized. Among all formulations of buccal films, F7 formulation exhibited good physical appearance, uniformity in weight, thickness, folding endurance, and surface pH. It showed better drug release of 80.62% in 60 min. The drug content is 98.73%. The drug diffusion can be extended upto 5 hour and the drug diffused is of 82.15%. The kinetic models used were zero order, first order, higuchi?s and peppa?s model. The kinetic analysis of drug release data indicated that the Lisinopril follows Higuchi plot. The FTIR spectroscopy propound that there was no chemical interaction between drug and excipients. The Scanning electron microscopy revealed that the F7 shows better surface morphology.

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