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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

TO ASSESS THE SHORT TERM AND LONG TERM VARIATION IN INTRA-OCULAR PRESSURE AFTER INTRAVITREAL INJECTION OF ANTI-VEGF

Laxmi, Dr. Deepak Mishra*, Prashant Bhushan, M. K. Singh

ABSTRACT

Purpose: To assess the short term and long term fluctuations in IOP variations after intravitreal injection of anti- VEGF (Bevacizumab). Design: A prospective hospital based clinical study. Method: 100 patients were screened and 65 patients were selected with indication of intravitreal anti-VEGF for the study. Baseline IOP was measured before injection, half hour after injection and at various follow up visits at 1 week, 3 week, 3 months and 6 months using applanation tonometer. IOP at 6 months was compared to baseline and to the number of injections received. Results: At 30 min, out of 65 patients, 59 had normalised IOP (<21mmHg) after receiving intravitreal anti-VEGF (96.1%) which was clinically significant (p value <0.001) and 6 patients had persistent IOP elevation of >30mmHg. At the end of 6 months, 10 patients had persistently elevated IOP (>21mmHg, p value <0.001) and rest had achieved normal IOP. Conclusion: Though majority of patients achieve normal IOP, monitoring is necessary to identify high risk patients who have delayed normalization of IOP immediately after receiving injection and also during long term follow up visits.

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