World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , 

World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

EVALUATİON OF ANTİ-BİOFİLM AND ANTİFUNGAL ACTİVİTİES OF MENTHA LONGİFOLİA ESSENTİAL OİL AGAİNST CLİNİCAL ISOLATES OF CANDİDA ALBİCANS

Uğur Tutar*

ABSTRACT

Mentha longifolia is traditionally used in the treatment of various diseases such as digestive and headache disorders. In current study, the essential oil of M. longifolia (EOML) was investigated for their antimicrobial, antibiofilm activity and chemical composition. The EOML chemical composition was analyzed by gas chromatography-mass spectrometry. Antimicrobial and anti-biofilm properties were determined using broth microdilution methods. According to the results of this study, the GC-MS profile highlights that the mains compounds were determined (61.40 %) Carvacrol, (17.38 %) o-Cymol, and (8.27 %) ?-Terpinene. The antifungal activity of the EOML was evaluated by the micro-dilution method on Candida albicans clinical isolates. It was determined that EOML inhibited 10 tested yeasts with Minimum Inhibitory Concentration (MIC) values in the range of 1.56- 3.12 ?l mL-1. Minimum Biofilm Inhibitory Concentration (MBIC) value was found to be range of 3.12-12.5 (?l mL-1) while the Minimum Biofilm Eradication Concentration (MBEC) value was found to be 3.12- 6.25 (?l mL-1). MIC value of the M. longifolia essential oil was applied onto the C. albicans biofilm formations. It was seen that the EOML reduced the cell viability in biofilm by 20.3-71.0 %. The findings of this study show that EOML has antifungal and anti-biofilm activity against C. albicans isolates. For this reason, M. longifolia essential oil may be considered as a potential agent for the treatment of C. albicans infections associated with biofilm.

[Full Text Article]

Powered By WJPMR | All Right Reserved

WJPMR