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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

CLINICAL EVALUATION OF IMPROVED ANOAC CREAM FOR EFFICACY AND ADVERSE DRUG REACTION IN PATIENTS WITH PERIANAL SYMPTOMS DUE TO ANAL FISSURE AND HEMORRHOIDS. A PROSPECTIVE OPEN LABEL STUDY

*Dr. Ashwin Porwal, Dr. Deepak Kulkarni and Dr. Paresh Gandhi

ABSTRACT

Anal fissure and hemorrhoids are painful and most common ailments found around the world. Common perianal symptoms include pain, bleeding, discharge, pruritus,[8] inflammation, swelling, pricking sensations. These wounds result in significant morbidity, sometimes requiring prolonged hospital stay, hospital readmission, home-nursing care that increases significant medical costs. These wounds are painful, malodorous lesions requiring constant care and adversely affect the quality of life. Use of modern medicines sometimes came with serious unwanted effects that leads treatment discontinuation and continuation of sufferings. Anoac cream is a new improved Ayurvedic polyherbal cream used by all the participants who is having perianal wound or condition. In this Study safety and efficacy were evaluated with help of scale in which From day zero to day 30 mean score of overall symptoms was analyzed. Total 7 patients reported adverse events like fever, rashes, redness of skin, increase in itching and not continued the treatment. Total 90 participants from Day zero Mean (SD) symptoms score was 29.8(3.40) that after treatment showed a significant improvement was on 1st week 23.9(3.05), 2nd week 19.08(2.12), 3rd week 10.98(2.04), 4th week 5.5(2.02). It Showed the significant reduction of overall symptoms and efficacy is improved formula. Individual Symptom scores reduced from maximum 5 to min1in the scale. Collection and use of symptoms in a scale found to be effective way to find the efficacy of this polyherbal formulation.

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