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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF HYDRAZONES DERIVED FROM IBUPROFEN

G. Jeevan Raghavendra, K. Bharatkumar and V. Siddaiah*

ABSTRACT

Thirteen new hydrazones 5a-m were prepared from commercially available Ibuprofen. The structures of the synthesized hydrazones were determined by the spectroscopic techniques like 1H NMR, 13C NMR, mass and IR spectral data. These compounds were screened against two Gram negative and two Gram positive bacteria viz., E. coli, P. aeruginosa, S. aureus and S. pyogenes respectively. Compounds 5h, 5i, 5j, 5k, 5l and 5m exhibited good antibacterial activity compared to the standard drug Norfloxacin.

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