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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

AN ANALYSIS OF HYPERANDROGENIC FEATURES AND OTHER CLINICAL CHARECTERISTICS IN NON OBESE PCOS- THE PHENOTYPIC DIAGNOSTIC CRITERIA

Dr. Malathi Balamurugan*, Dr. Balamurugan Maruthamuthu, Gomathi Ramanathan

ABSTRACT

BACKGROUND: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrinopathy in
premenopausal women. AIM: To analyze the clinical presentation in non-obese women with Polycystic ovary
syndrome (PCOS). METHODOLOGY: The data of the anthropometric measurements, clinical manifestations of
hyperandrogenism, menstrual history and life style were collected from 24 young non-obese (selected according to
BMI) patients with polycystic ovary syndrome and compared with 30 regularly menstruating age matched BMI
matched normal women. Unpaired Student t test for continuous variables and chi square test for categorical
variables, Pearsons correlation and Binary logistic regression analysis was done to bring out the association
between the variables. RESULTS: Among the hyperandrogenic features the incidence of Hirsutism (defined as a
Ferriman-Gallwey score > or = 6) was 62.5%, fourth highest prevailing androgenic sign, next only to dandruff
(91.76%), Acne (75%) and androgenic alopesia (66.66%). Menstrual history: 66.66% had Oligomenorrhea, 62.5%,
Chronic pelvic pain, 54.16% Premenstrual tension 25% History of similar problems in family 25%, along with
significantly altered life style parameters. Waist circumference, W / H ratio, Age of Menarche (years), Hirsutism
score were significantly correlated with p value of <0.001, 0.01,< 0.001,< 0.001 with non-obese PCOS. Of the
hyperandrogenic parameters, Acanthosis nigricans , Hidradenitis Suppurtiva
and Androgenic alopecia came out as
significant individual predictors of a person to have PCOS who is of ideal and lean weight with p value
< 0.05,
<0.001, severe hyperandrogenism, altered lifestyle, disturbed menstruation and related factors than controls, which may
have severed health implications later in life.

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