ETHOSOMAL GEL: A NEW STRATEGY FOR GOUTY ARTHRITIS
*Varsha K. and Arun Kumar K. V.
Gouty arthritis is a sudden, painful attack of joint inflammation due to over production and deposition of uric acid crystals in the tissues and blood or more commonly. This acid can form needle-like crystals in a joint and cause of a sudden onset of a painful, hot, red, swollen joint particularly in the first metatarsophalangeal joint. The most common factors that increases the chance of gouty arthritis are excess consumption of purine rich foods, alcoholic drinks especially beer, beverages sweetened with high-fructose corn syrup, obesity. It can be diagnosed by detecting uric acid (monosodium urate) crystals in an aspirated sample of the affected joint fluid. New treatments choices available today are NSAIDs, corticosteroids, xanthine oxidase inhibitors. The basic idea behind incorporating NDDS in herbal medicine is that, it may help in increasing the efficacy and reducing the side effects of various herbal compounds and herbs. Here we are incorporating the herbal extracts into ethosome which will target the desired site and potentiate the therapeutic action and the bioavailability of the formulation is also increased. Another advantage is that, the bioactive constituents in the herbal formulations show enhancement in stability, sustained release from formulation, protection from toxicity and improved therapeutic efficacy. The main purpose of developing alternative drug delivery technologies is to increase efficiency and safety in the process of drug delivery and to make it more patient compatible.[Full Text Article]