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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

EVOLUTION OF ANAEMIA IN PULMONARY TUBERCULOSIS PATIENTS ON ANTI-TUBERCULOSIS THERAPY

Williams Bitty Azachi*, Kanayo Eugene Ikeh and Bello Bashir

ABSTRACT

Anaemia of chronic disease (ACD) is a form of anaemia seen in chronic illnesses such as in active pulmonary tuberculosis (TB) patients. In such cases, iron is sequestered in macrophages limiting availability to invading organisms in a bid to control the infection. Our research bordered on finding out if the anaemia will be resolved as tuberculosis treatment proceeds, without need for iron-rich supplements. We recruited 110 active pulmonary tuberculosis patients and 110 age- and gender-matched apparently healthy controls to this study and compared their haemoglobin concentration values. The tuberculosis patients were further grouped into 3: Group 1 comprising of newly diagnosed patients before start of treatment; Group 2 comprised of TB patients 2 months after start of treatment, and Group 3 had patients 6 months after start of treatment. The haemoglobin concentration of patients in each group were compared to the controls. This study found a significantly lower haemoglobin concentration in TB patients across all age groups and gender when compared to the controls (P-value<0.05). The mean haemoglobin concentration (g/dl) in Groups 1-3 were 7.58±0.48, 10.58±2.26 and 13.46±3.40 respectively, showing a gradual increase in haemoglobin concentration as treatment proceeded. A comparison of haemoglobin concentration in Group 3 patients with the controls was not statistically significant (P-value=0.504) showing that anaemia had been completely resolved. We conclude that anaemia is an accompanying feature of pulmonary tuberculosis but can be resolved by treating the primary disease without need for iron-supplements.

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