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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

COMPARISON OF ANTIMICROBIAL ACTIVITY OF LOCALLY PRODUCED SOAPS AND CONVENTIONAL MEDICATED SOAPS ON BACTERIAL ISOLATES FROMSKIN AND WOUND

Wemedo Samuel Amadi*, Akani Nedie Patience and Olaolu Jeremiah Olayiwola

ABSTRACT

Antimicrobial activity of Locally made and Conventionalcustomized medicated soaps sold and widely used by the residents of Port Harcourt Metropolis. Rivers State, Nigeria was examined against some clinical bacterial isolates from skin surface and wound. Clinical isolates used were Staphylococcus aureus and Pseudomonas aeruginosa. the results showed that the test organisms were sensitive to the soap samples at different concentrations. As the concentration increased the zones of inhibition significantly increased. The results obtained showthat among the conventional customized medicated soaps, the highest effectiveness was carried out by Dettol (25mm) at 500mg/ml and Safeguard (24mm) at 500mg/ml against S. aureus and P. aeruginosa.In the category of locally made soaps, the red soap (LPRS) was discovered to be more effective on all the isolates (S. aureus,11.5mm and P. aeruginosa, 16.5mm) at 500mg/ml, as compared to locally produced black soap (LPBS) with this effectiveness S. aureus,8.5mm and P. aeruginosa, 12mm. The percentage of activity of the soaps on the test organisms showed that S. aureus displayed higher resistant to most of the soaps compared to P. aeruginosa. The Minimum Inhibitory Concentration (MIC) of the soaps with efficacy was found to be 125mg/ml on S. aureus and 250mg/ml on P. aeruginosa while the Minimum Bacteriocidal Concentration (MBC) was 250mg/ml for all theisolates.

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