Abstract

Fadhil Jawad Al-Tu’ma*, Sattar J. Hatrosh and Hayder B. Al-Ghreaty

ABSTRACT

Background: Metabolic syndrome is a cluster of conditions associated with increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels, increasing risk of heart disease, stroke and diabetes. The atrial natriuretic peptides are secreted from cardiomyocytes in response to cardiac wall stress and play an important role in the regulation of blood pressure, intravascular volume, and cardiac remodeling; the natriuretic peptides also may exert a direct influence on lipid and glucose metabolism. Objectives: The current study aimed to investigate the role of atrial natriuretic peptide levels in metabolic syndrome of Iraqi patients. Methods: This study was conducted at Al-Hussein Teaching Hospital, Kerbala – Iraq from June, 2016 to Dec., 2017. One hundred twenty four patients with metabolic syndrome were included in this study. The subjects were interviewed for full history and physical examination. Diabetes was defined by either a history of fasting glucose ? 126 mg/dl (7.0mmol/l) or the use of insulin or hypoglycaemic medications. Serum atrial natriuretic peptide (ANP) levels were measured by ELISA kit. In addition to body mass index, lipid profiles, blood pressure, fasting glucose was measured. Results: The results show that there is a significant decrease in serum levels of atrial natriuretic peptide hormone in diabetic metabolic syndrome patients compared with non-diabetic metabolic syndrome patients in both sexes (P value< 0.05). Conclusion: We conclude that there was a significant association between lower ANP concentration and metabolic components studied. These findings raise the possibility that low level of ANP are a manifestation of metabolic syndrome, which might have pathophysiological implications.