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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

COMPARATIVE STUDY OF ENDOPHYTIC FUNGAL METABOLITE ISOLATED FROM BLACK TURMERIC (CURCUMA CAESIA ROXB.) IN ROS ASSOCIATED CAENORHABDITIS ELEGANS MODEL SYSTEM

Homen Phukan*, Pradip Kr. Mitra and Mowsam Saikia

ABSTRACT

Free radicals containing oxygen, known as reactive oxygen species (ROS) is one of the important factors of aging-associated diseases. Excess production of ROS and insufficient cellular antioxidant reverse compromise cell repair and metabolic homeostasis, which serves a mechanical switch for a variety of aging-related pathways. Black turmeric (Curcuma caesia Roxb.) is a perennial herb, native to North-East and Central India, with bluish-black rhizome of high economical importance because of its medicinal values. It was reported that curcumin from this rhizome has anti-inflammatory and in vitro antioxidant activity. In this review, we discuss the possible role of major endophytic fungi present inside the healthy tissue of rhizome of black turmeric coupled with analysis of in vivo antioxidant and antiaging potential of the fungal metabolite by employing a popular experimental model-Caenorhabditis elegans. Because endophytes are a potential source of novel natural products for exploitation in medicine, agriculture, and industry and the endophytes of black turmeric have yet not explored in comparison to Curcuma longa.

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