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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

THE PROTECTIVE EFFECTS OF BEETROOT AGAINST DEXAMETHASONE INDUCED DAMAGE IN LIVER, KIDNEY AND HYPERLIPIDEMIC EFFECTS IN MICE

Mohammed Abdul Muttalib Abdul Bari*, Haider M. Badea Albadri and Hasan Fadhil Hussein

ABSTRACT

Background: beetroot is grown in many countries over the world, is frequently consumed as part of the normal diet, and usually used in manufacturing as a food colouring agent. Beetroot is also one of the many vegetables that contain a group of highly bioactive pigments such as betalains and a number of research have mention betalains to have to have a powerful antioxidant and anti-inflammatory effects in vitro and in vivo animal models. Aims and Objectives: To explore possible protective effects of beetroot extract against damage induced by dexamethasone on liver, kidney and possible hypolipidemic effects in mice. Materials and Methods: Thirty male Swiss albino mice aged nine to10 weeks and weighing 25 to 30 g were used throughout the study. After tow-weeks acclimatization period, the selected animals of nearly a similar weight were divided into three experimental groups so as to keep more or less the same mean body weight within the individual groups. Damage induced by dexamethasone at the dose of 4mg/kg body weight per day. Results: it was found that dexamethasone increase all lipid profile (except HDL concentration) significantly with a marked liver and kidney injury and on the other hand the present study confirm the protection of beetroot juice against oxidative damage on liver, kidney and a significant decrease of lipid profile in mice. Conclusion: Beetroot have shown to have a significant medical values and positive health effects, its significantly decrease a damge effects on liver kidney and shown a significant decrease of lipid profile in mice subjected to dexamethasone.

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