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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

COMPARATIVE PROTEOMIC ANALYSIS OF SELECTED CLINICAL ISOLATES OF MDR-TB OF ANDAMAN AND NICOBAR ISLANDS

Homen Phukan* and Dr. Pradip Kr. Mitra

ABSTRACT

Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb). The problem of TB is increasing worldwide due to prevalence of multi-drug-resistant (MDR) strains and co-infection with human immunodeficiency virus (HIV). India is the country with the highest burden of TB. The Andaman & Nicobar Islands, an archipelago of 527 islands in the Bay of Bengal, is administratively a Union Territory of India. According to the survey of Tuberculosis conducted during 2006-2009 in that place, 8%-10% were found as MDR out of the total positive isolates detected. Tuberculosis is a major public health problem in the islands, particularly among the Nicobarese tribe. This review is designed to analyze and compare the protein expression profile of M. tuberculosis MDR isolates from selective hospitals of Andaman & Nicobar Islands to identify as well as characterize proteins, which could be used as a drug target or diagnostic marker for future designing of valuable TB vaccine or TB rapid test.

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