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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

ACUTE DERMAL TOXICITY STUDY OF A SIDDHA POLYHERBAL FORMULATION KARAPPAN ENNAI IN RATS

Dr. Rajeshwari E.*, Gandhimathi S., Meenakumari R. and Muralidharan P.

ABSTRACT

Karappan ennai,[1] a compound of Siddha polyherbal formulation is indicated for skin diseases particularly Karappan[2] (Atopic dermatitis) in children. So far no safety profile has been published for this formulation. Hence in the present study acute toxicity study for Karappan ennai was carried out as per based on the OECD (Organization for Economic Co-operation and Development) Guidelines 402.Therefore, evaluating the toxic characteristics of a given substance is considered important for the protection of public health, since the exposure to the chemical is hazardous and can lead to adverse influences on the human body. The objective of this study is to evaluate the in vivo acute dermal toxicity of polyherbal formulation of Karappan ennai. The Karappan ennai at a dose of 15ml/kg and 30ml/kg of body weight did not produce treatment related signs of toxicity or mortality in all rats tested during the 14 day observation period. The results of this study suggest that the polyherbal formulation of Karappan ennai do not cause any apparent in vivo acute dermal toxicity study.

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