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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

RITUXIMAB IN STEROID RESISTANT CHILDHOOD PEMPHIGUS

Dr. Sharmila Patil*, Dr. Ratnakar Shukla, Dr. Sheena Kapoor and Dr. Mamta Kamath

ABSTRACT

Pemphigus vulgaris is an autoimmune vesico-bullous disorder involving the skin and mucous membrane characterized by painful erosions in the mucosae as well as flaccid vesiculo bullae on the skin. Pemphigus can affect all age group. The exact prevalence of paediatric pemphigus is unknown, but probably it affects 1.4 – 3.7% of total cases of pemphigus.[1][2][3] Rituximab is increasingly used in adult patients with pemphigus vulgaris who are nonresponders to conventional line of therapy.[4] However there is limited clinical data on safety and efficacy of rituximab in the paediatric age group. Here, we report a 15-year-old boy of pemphigus vulgaris who was treated with rituximab and achieved complete remission.

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