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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

VIOLATIONS OF MICROECOLOGY AND LOCAL FACTORS OF ORAL CAVITY PROTECTION IN PATIENTS WITH HEPATOBILIARY PATHOLOGY

Malika Kh. Ibragimova* and Khaydar P. Kamilov

ABSTRACT

Quantitative and qualitative indices of the oral fluid microflora are presented in patients with hepatobiliary pathology suffering from chronic cholecystitis. It was found that the total number of the facultative group of microbes exceeds the amount of anaerobic microbes. Among gram-positive cocci, staphylococci predominate. The number of gram-negative microbes belonging to the genus Escherichia and Proteus has significantly increased. Among the anaerobic group of microbes, the number of lactobacilli decreased almost 2 times. In determining the colonization resistance of microbes in various biotopes of the oral cavity in patients with chronic cholecystitis, significant changes occurred, compared to healthy individuals, it was possible to establish a reliable increase in colonization in all biotopes of gram-negative flora and fungi of the genus Candida. Local protective factors were studied: lysozyme titer, phagocytosis index and level of secretory immunoglobulin A (sIgA), the results showed the development of immunodeficiency in all studied parameters.

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