PULSATILE DRUG DELIVERY SYSTEM – A REVIEW
Sinchu Yesudanam*, Soumya SP, Anusree S., Dr. William Arputha Sundar AS and Sam Jeeva Kumar E.
Controlled drug delivery systems have acquired a center stage in the arena of pharmaceutical R&D business. Such systems offer temporal or spatial control over the release of drug and grant a new lease on life to a drug molecule in terms of patentability. Controlled drug delivery systems release the drug with constant or variable rates. However, there are certain conditions for which such a release pattern is not suitable. These conditions demand release of drug after a lag time. In other words, it is required that the drug should not be released at all during the initial phase of dosage form administration. Such a release pattern is known as pulsatile release. There are certain conditions which demands such systems they include; many body functions that follow circadian rhythm. A number of hormones like rennin etc shows daily fluctuations in the blood stream. Then the same is observed in certain diseases like the bronchial asthma, ulcer , etc display time dependence. This system is also preferable for the drug which produces biological tolerance and the drugs which undergo extensive first pass metabolism. All these conditions demand for a time programmed therapeutic scheme releasing the right amount of drug at the right time. This requirement is fulfilled by pulsatile drug delivery system only. Thus such systems is characterized by a lag time that is an interval of no drug release followed by rapid drug release.[Full Text Article]