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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

INTERCALATION OF ITRACONAZOLE INTO MONTMORILLONITE: EFFECT ON RELEASE OF DRUG

Dr. Atul Anand Phatak* and Pratik S. Rahane

ABSTRACT

Itraconazole (ICZ), an antifungal drug, which is poorly water soluble which makes it difficult to form a stable formulation with enhanced safety and therapeutically effective formulation. Nano minerals help by modulating drug delivery. The study deals with the investigation of itraconazole (ICZ) intercalated into montmorillonite (MMT) by ion exchange technique. Intercalation which is carried out acts as reversible isomorphous substitution which ensures that the cation is displaced in the media. This helps in modulating the drug delivery to overcome the toxicity and increases its efficacy. Effect of different reaction conditions like pH and temperature were studied. Optimum intercalation (90.69%) was achieved by ion exchange technique. X-ray diffraction, Fourier Transform Infra-red spectra indicated the ICZ intercalated into the clay interlayer space. The effect of intercalation of ICZ on modification of release pattern of drug was observed and showed promising results. Nanocomposite showed prolonged release of ICZ with possible improved antifungal activity in the body.

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