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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

IN SILICO STUDIES ON DENGUE AND POLIO VIRAL NON STRUCTURAL PROTEINS WITH SELECTED MENTHA ARVENSIS LEAVES CONSTITUENTS

Ramya M., Anushree S., Archana S, Smriti Chawla, Bhavya M, *Balasubramanian Sathyamurthy

ABSTRACT

Mentha arvensis belongs to family Picornaviridae. The leaves of Mentha arvensis are used as herbs in Ayurvedic medicine. The plant has been shown to possess sedative–hypnotic, anti–inflammatory antioxidant, hepatoprotective antibacterial, antifertility and anti-Candida activities properties. The GCMS results showed the presence of 4 compounds in Mentha arvensis with a wide variety of biological activities. The comparative study of 5 non-structural proteins for dengue along with 6 non-structural proteins for Polio virus was carried out through In Silico methods. In this study we examined the binding affinities of 4 ligands with 11 proteins of both viruses. By our virtual screening and molecular docking result, we found that the 3, 7, 11, 15-Tetramethyl-2-hexadecen-1- ol had the highest binding affinities with all the 11 proteins and we also predicted the binding site amino acid residues and the type of hydrogen bonding.

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