FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF ATENOLOL HYDROCHLORIDE
Priyadharshini, *Akelesh T., Sam Johnson Udaya Chander J., Kandasamy C. S. and Venkatanarayanan R.
The main objective of the present work was to develop sustained release matrix tablets of Atenolol HCl. To reduce the frequency of administration and to improve the patient compliance, a once daily sustained release formulation of Atenolol is desirable. So sustained release Matrix Tablet Of Atenolol HCl was designed by using different polymers viz. Hydroxy Propyl Methyl Cellulose (HPMC), Sodium Carboxy Methyl Cellulose (NaCMC) and Guar Gum Varying ratios of drug and polymer were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by Single polymer, combination of two different rates controlling material and triple mixture of Polymer. The IR study revealed that there was no chemical interaction between drug and excipients. The granules were prepared by wet granulation method. Precompressional parameters i.e. angle of repose, percent compressibility, and Hausner?s ratios were studied. These results indicate that granules are good flowing characteristics. After evaluation of physical properties like Weight variation, Hardness, Thickness, Friability of tablet, the different formulations checked for the Percentage Drug content which having good uniformity. The in vitro release study was performed in phosphate buffer pH 7.4 up to 12 hrs. The effect of polymer concentration were studied. Dissolution data was analyzed by Percentage cumulative drug release. Matrix tablets studied for the different polymer ratios and performance checked for different concentration ratios. The results of drug dissolution studies showed improved drug release, retardation effects of the polymers and could achieve better performance. It was observed that matrix tablets contained polymer blend of HPMC / Sodium CMC were successfully sustained the release of drug upto 12 hrs. Swelling Index of different formulations were studied. Stability studies (40±2ºC/75±5% RH) for 3 months indicated that Atenolol was stable in the matrix tablets.[Full Text Article]