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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

BILATERAL PUTAMINAL NECROSIS AND BLINDNESS GIVING LATE FINDING AFTER METHANOL INTAKE: CASE REPORT

Dr. İrem Akin Şen*, Dr. Metin Kilinç and Prof. Dr. Hülya Sungurtekin

ABSTRACT

The methyl alcohol is a clear, odorless and toxic chemical substance which is found in many products such as antifreeze, defroster solutions, paint removers, and cologne and of which taste is similar to the ethyl alcohol.[1] Although methanol itself is not very toxic, its metabolites are very toxic. It is metabolized to the formaldehyde by the alcohol-dehydrogenase and then to the formic acid. These metabolites are responsible for the metabolic acidosis, blindness, cardiovascular instability and methanol toxicity that can cause to the death.[2] Poisoning frequently happens after the oral intake; however, absorption can happen through the lungs and skin. It reaches the high levels in the kidney, liver and gastrointestinal system following the intake; but, it is also found in the vitreous humor and optic nerve at the high levels.[3,4]

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