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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

COMPARISON OF INTRAVENOUS ESMOLOL WITH INTRAVENOUS LABETALOL FOR SUPRESSION OF HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION DURING GENERAL ANAESTHESIA

Dr. Karthic Ekambaram* and Dr.Venkatraman.V

ABSTRACT

Objective: The present study compared the efficacy of esmolol and labetalol, for attenuation of sympathomimetic response to laryngoscopy and intubation. Materials and Methods: This is a Comparative observational study in which 60 ASA Grade I and II patients aged 18-45 years undergoing elective surgical procedures, requiring G.A. and orotracheal intubation were taken up for the study. Patients were allocated to any of the two groups (30 each). Group E (Esmolol) were given 1.5mg/kg of drug diluted with 0.9% saline 10ml IV, Group L (Labetalol) were given 0.4mg/kg of the drug diluted with 0.9% saline 10ml IV. All the patients were subjected to the same anaesthesia technique. HR, SBP, DBP, MAP, RPP were recorded prior to intubation, then 0 minute, 2 min, 3 min and up to 5 min post intubation. Results: Compared to esmolol, labetalol significantly attenuated HR, SBP, DBP, MAP and RPP during laryngoscopy and intubation. Conclusion: Labetalol is a better agent than esmolol in attenuating the sympathomimetic response to laryngoscopy and intubation.

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