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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

USE OF AUTOLOGOUS PLATELET RICH PLASMA (PRP) IN DIABETIC FOOT ULCERS TREATMENT

Dr. Hemant Sharma* and Anubha Sharma

ABSTRACT

Introduction: India has 42 million cases of Diabetes, the most common complication of which is Diabetic Foot Ulceration (DFU), affecting 15% of Diabetic population in a lifetime. Non-healing diabetic foot ulcers and the resulting potential amputations present significant costs to the healthcare system and reduce patient’s quality of life. Emerging cellular therapies such as platelet – rich plasma (PRP) can have an adjunctive role in a standardized, quality treatment plan. PRPT is a rich source of locally active (bioregulating) growth factors and cytokines that improve conditions of wound healing. The aim of this study was to assess wound healing in DFU treated by PRP. Materials and Methods: The study was conducted in Orthopaedics Department, Guru Nanak Dev Hospital, Govt. Medical College, Amritsar from December 2016 to July 2017 on patients admitted for treatment of diabetic foot ulcers. 12 patients of either sex with diabetic foot were selected. PRP dressings were done on 1st, 7th and 21st day, saline dressings were done in the rest of the week and results seen at the end of 8th week. Conclusion: Autologous PRP holds great potential in treatment of diabetic ulcer of foot with re-epithelialization at a faster pace possibly due to various growth factors present in it, although duration of wound and grade of wound are also important prognostic factors.

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