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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

A STUDY ON CARDIAC EFFECTS OF ACUTE ORGANO-PHOSPHORUS COMPOUND POISONING AND ITS POSTMORTEM TOXICOLOGICAL FINDINGS

Dr. V. N. Alaga Venkatesan, *P. G. Anandhi, P. Shridharan and J. Durga Lakshmi

ABSTRACT

Context: Mortality and morbidity associated with organo-phosphorus compound poisoning are well known facts. Even though the most common complication recognized is respiratory failure, cardiac complications also occur after OP poisoning. The study is undertaken with an aim to assess the extent of the myocardial injury in OPC poisoning using clinical, ECG & biochemical parameters & to correlate them with the outcome of the event including the postmortem external toxicological findings of Heart. Aims and objectives: 1.To study the prevalence of OPC Poisoning in our hospital. 2. To study the prevalence of myocardial injury in OPC poisoning & to correlate it with in hospital mortality. 3. To study the postmortem findings of Heart in OPC Poisoning. Settings and design: Hospital based Prospective Observational study Materials and methods: The study was conducted on 50 patients who were admitted in Govt. Rajaji hospital, Madurai with history and features of OPC poisoning who fulfilled the inclusion & exclusion criteria. Statistical Analysis: Using statistical software, frequencies, range, mean, standard deviation and percentages were calculated. Results: In our study, out of 19 deaths noted, five died within 24 hours of consumption, 5 within three days and the rest died after 72 hours of consumption, which correlated directly with ECG changes, serum CK-MB and serum Troponin T levels. This observation indicates that the EARLY deaths are due to cardiac cause. Conclusions: Cardiac effects of acute Organo-phosphorus compounds should be anticipated during the first few days of exposure to prevent mortality in addition to respiratory failure.

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