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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF CARVEDILOL WITH NATURAL SUPERDISINTEGRANT AND SYNTHETIC DISINTEGRANTS

Reena Thakur*, Sunidhi Mahant, Shivali Singla and Sachin Goyal

ABSTRACT

Introduction: Immediate Release Tablets are those tablets which are designed to disintegrate and release their medication with no special rate controlling features, such as special coatings and other techniques. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because of their quick onset of action easy administration, economical and better patient compliance. Methodology: In present research work the immediate release tablets of Carvedilol were prepared using natural or synthetic superdisintegrantsby wet granulation method. At s initial stage preformulation studies were carried out to check physicochemical properties of the drug and compatibility with excipients. Nine formulations were prepared and evaluated for minimum possible disintegrating time to optimize the best formulation.First three there of them contains synthetic disintegrant i.e. Crospovidone, another three contain natural superdisintegrants, and for last three contain Sodium starch glycolate. All were evaluated at pre and post compression phases also. All the batches, then further evaluated for hardness, thickness, weight variation, drug content uniformity, In vitro disintegration time andIn vitro release studies. Results and Conclusion: All the prepared formulations show significant result obtained by Pharmacopoeial quality control test. On the basis of disintegration test observations F3 and F6 formulation were found to be best among all batches.

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