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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

EFFECTS OF ETHANOLIC SEED EXTRACT OF TETRACARPIDIUM CONOPHORUM ON BODY WEIGHT, FOOD-INTAKE, WATER-INTAKE AND BLOOD GLUCOSE LEVEL OF FEMALE WISTAR RATS

Nancy N. Njoku-Oji*, Scholastica O. Ahiwe, Stephen O. Maduka, Peter N. Ogueche, Izuchukwu A. Okafor, Ijeoma C. Enemuo, Johnson U. Agbai and Njoku O. Ifegwu

ABSTRACT

Objective: This study was carried out to investigate the effects of ethanolic seed extract of Tetracarpidum conophorum on blood glucose level, food-intake, water-intake and body weight of normal female wistar rats. Methodology: Thirty-two female wistar rats weighing between 140- 200g were purchased from the Animal house of Human Physiology Department Nnamdi Azikiwe University Nnewi. They were acclimatized for two weeks after which they were divided into 4 groups of 8 rats each and housed in cages. The groups were designated as groups A, B, C and D. Group I served as control group that received only distilled water while the other groups B-D served as test groups that were administered ethanolic seed extract of T. conophorum orally throughout a period of 14 days. The extract was administered using oral cannula at doses of 200mg/kg, 400mg/kg and 600mg/kg to groups B, C and D respectively. Results: There was a significant (P<0.05) decrease in body weight in group D when compared with the control. There was insignificant (P>0.05) decrease in food intake in all test groups when compared with the control. There was insignificant (P>0.05) increase in water intake in all test groups when compared with the control. There was a significant (P<0.05) decrease in blood glucose level in group D when compared with the control. Conclusion: This study has revealed that Tetracarpidium conophorum may have control effect on hyperglycemia and obesity hence its consumption by diabetic and overweight patient is highly recommended. However, this should be done with caution to avoid toxicity.

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