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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301

ICV : 78.6



Dr. Muhammad Atif*, Dr. Areesha Seemab and Dr. Muhammad Nabeel Akbar


Background: Diabetes mellitus affects heart in multiple ways and can affect virtually any part of heart specifically cardiac myocardium. Diastolic dysfunction has been described as an early sign of diabetic heart muscle disease preceding the systolic damage. Hence this involvement can severely affect the cardiac contractility resulting in severely debilitating symptoms of cardiac failure and hampering life. The objective of this study Frequency of diastolic dysfunction in cases of Diabetes Mellitus. Methods: In this descriptive case series, 75 consecutive patients with diabetes mellitus having normal blood pressure and normal resting electrocardiogram and without any symptoms of heart failure were selected. Duration of the study was 6 month from July 2017 to December 2017 at Jinnah Hospital, Lahore. 75 cases of diabetes mellitus of both gender i.e. male/female with age more than 40 years and duration of DM of at least 2 years and of type II DM were included. The cases with previous history of acute coronary syndrome, valvular disease, liver or renal disease were excluded. Presence or absence of diastolic dysfunction will be documented in each case. Results: Of the total, 35 (46.6%) of patients had diastolic dysfunction with male predominance. Conclusion: Diastolic dysfunction is seen in almost half of the cases with DM type 2. Diastolic dysfunction can occur in diabetic patients even in young patients and those with shorter duration of disease. Diastolic dysfunction can be used as an early indicator, as it is a precursor to increased LV hypertrophy and clinical left ventricular dysfunction.

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