World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

USE OF CORTICOSTEROIDS ASSOCIATED WITH EXERCISES AND INTAKE OF ω3: EFFECTS IN BONE, MUSCLE AND IN PLASMA LIPIDS

Maricelma Da Silva Soares De Souza, Sandra Maria Barbalho*, Élen Landgraf Guiguer, Patrícia C. S Bueno, Tamiris Ferreira Da Rocha and Julliane Freitas Chaves

ABSTRACT

Glucocorticoids (GC) are one of the most effective anti-inflammatory drugs for the treatment of several chronic inflammatory processes and immune diseases. Despite the many positive effects, they are also associated with several side effects such as osteoporosis, and muscle mass loss. On the other hand, the use of ?3 and the practice of exercises may produce health benefits on these parameters. Based on these facts, the aim of this work was to evaluate the effects of the use of GC, intake of omega 3 and practice of physical activity. Sixty male Wistar rats were selected for this study according to the following groups: G1: control group; G2: GC group; G3: GC and practice of exercises; G4: GC, practice of exercises and intake of ?3; G5: GC and use of ?3 and G6: ?3 group. The results of our study showed that the use of GC increased loss in the body weight and in muscular mass but did not interfere in the cholesterol total, triglycerides and HDL-c levels. The association of GC with exercises produce similar effects to those found in animals treated only with GC. When associating GC, exercising and Omega 3, we observe improvement in HDL-c levels but no differences were found in the other parameters. The use of GC and Omega 3 resulted in effects similar to those found in the group that received only GC.

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