CORRELATION BETWEEN ANTHROPOMETRIC PARAMETERS WITH LOW DENSITY LIPOPROTEIN RECEPTOR (A370T) GENE POLYMORPHISM IN TYPE II DIABETES PATIENTS OF IRAQI POPULATION
Fadhil Jawad Al-Tu’ma*, Hassan Mahmoud Abu Al-Maali and Marwa Ali Zghair
ABSTRACT
Background: (A370T) is a SNP in the 370th nucleotide in exon 8 of the low density lipoprotein receptor (LDLR) gene where Guanine (2-amino-6-oxy purine) transported to Adenine (6-amino purine) and this substitution is of transition type as each of Guanine and Adenine are purine nitrogen base. The (A370T) SNP causes an amino acid replacement (Alanine to Threonine) in the translated polypeptide. Aim: This study was designed to assess the relationship between the low density lipoprotein receptor (A370T) single nucleotide polymorphism and different anthropometric parameters in type 2 diabetes mellitus patients in Kerbela city. Materials and Methods: A case-control study of 180 patients (90 male and 90 female) with type II diabetes mellitus. Body mass index, serum lipid profiles and fasting blood sugar were measured in sera of each patient (males and females) and the statistical analysis was made by SPSS 22. Results: The results attained in the current study showed that the fasting blood glucose and glycated hemoglobin were significantly higher (p
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