Abstract

Siham Ouguellit*, Jihane Ouchraa, Sarra Akla, Hamza Ettahri, Aicha Kharbach and Hassan Errihani

ABSTRACT

Background: Uterine sarcomas (US) area rare and aggressive malignant tumor, Due to their non-specific signs and symptoms, they are commonly diagnosed in advanced stage, the treatment includes a complete surgery and no standard recommendation is available for adjuvant therapy. Methods: This was a retrospective study of patients diagnosed and treated at our center for a histologically confirmed uterine sarcoma from January 2008 to January 2012. Results: We identified 10 patients with US during this period, 6 of them were leiomyosarcomas, 3 cases of endometrial stromal sarcoma and 1 case of high grade polymorphic sarcoma. The median age at presentation was 54.7 years, vaginal bleeding and the presence of pelvic mass were the two main symptoms, all patients underwent total hysterectomy with bilateral salpingo-oophorectomy, 3 patients received adjuvant radiotherapy, 2 of them relapsed at 4 months and 2 years, they received palliative mono-chemotherapy by adriamycin (60mg/m2). At the end of our follow-up, only one patient survived without evidence of recurrence 5 years after diagnosis. Conclusion: Uterine sarcomais a rare subtype of uterine cancers with a poor prognosis, Tumor stage is the most important prognostic factor, therefore, early diagnostic workout and optimal therapy management are essential.