IN A STUDY ON TYPE 1 DIABETES MELLITUS TREATED WITH METFORMIN
S. V. R. Govardhan Reddy, K. Krishna Vamsi, G. Ramesh, Satheesh S. Gottipati and Dr. P. Srinivasa Babu
ABSTRACT
Metformin is a biguanide anti-hyperglycemic agent used for treating non-insulin dependent diabetes mellitus (NIDDM) It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. Metformin may induce weight loss and is the drug of choice for obese NIDDM patients. Retrospective study suggest that use of metformin in patients with type DM reduces glucose concentration, and decreases metabolic syndrome prevalence. Addition of metformin to insulin therapy promote weight control, and reduce insulin dose requirements in patients with type 1 diabetes has been assessed in systematic reviews.
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