KUPILU – VARIOUS SHODHANA PROCEDURES WITH HPLC ANALYSIS
Dr. Megha R. Survase*, Dr. Aparna S. Taware and Manisha R. Survase
ABSTRACT
Kupilu is a poisonous drug used as medicine in Ayurvedic formulations, after its shodhana procedure. Many procedures are explained in Ayurvedic classics for Shodhana of a toxic drug to reduce its toxic effects. This study consists of 8 different types of shodhana procedure. HPLC analysis was done for each sample to find out percentage decrease in Strychnine and Brucine. The study was conducted to understand the role of different Shodhana procedures in changing its chemical constituents. The media selected for Shodhana were cows milk, cows dung, cows urine, cows ghee and kanji. Total eight samples were taken for the study. All the eight shodhana procedures brought about significant changes in Strychnine and Brucine. The most remarkable change occurred in the cows milk shodhita sample followed by cows urine +cows milk +cows ghee sample showing remarkable changes.
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