World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

World Journal of Pharmaceutical and Medical Research (WJPMR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Indian Science Publications , Cosmos Impact Factor , Research Bible, Fuchu, Tokyo. JAPAN , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , International Innovative Journal Impact Factor (IIJIF) , Scientific Journal Impact Factor (SJIF) , Global Impact Factor (In Process) , Digital Online Identifier-Database System (DOI-DS) , Science Library Index, Dubai, United Arab Emirates , Eurasian Scientific Journal Index (ESJI) , International Scientific Indexing, (ISI) UAE , IFSIJ Measure of Journal Quality , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

Abstract

DEVELOPMENT AND VALIDATION OF NEW UV SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF BENFOTIAMINE IN BULK AND SOLID DOSAGE FORM

Niraimathi. V* and Siva Sankari K.A.

ABSTRACT

Benfotiamine (synonym S-benzoylthiamine-O-monophosphate) is the precursor of thiamine which is a water soluble vitamin. Benfotiamine is fat soluble, a characteristic that allows it to enter cells more readily than thiamine and thus helps to prevent diabetes-related dysfunction within the cells. This enhanced bioavailability makes benfotiamine particularly effective in treating hyperglycemia related damage to tissues and organs. Two simple, precise, accurate UVspectrophotometric methods namely dual wavelength spectrophotometric method and difference UV spectrophotometric method have been carried out using 0.1 N HCl as solvent. The drug obeyed Beer’s law in the range between 4-20?g/mL. The overall percentage recovery was found to be 99-101% which indicates the accuracy of the proposed method. The methods have been validated as per ICH guidelines and could be applied in future analysis of Benfotiamine formulations.

[Full Text Article]    [Download Certificate]

Powered By WJPMR | All Right Reserved

WJPMR